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KMID : 1140120090140040309
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Cancer Prevention Research
2009 Volume.14 No. 4 p.309 ~ p.314
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Urushiol Induces Growth Inhibition and Apoptosis in MCF-7 Human Breast Cancer Cells
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Kim Sea-Ho
Jeong So-Hyun
Hossain Mohammad Akbar
Kim Min-Young
Kim Dong-Hwan
Kim Jin-Ah
Yoon Jeong-Hyun
Na Chun-Soo
Kim Nam-Deuk
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Abstract
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In this study, we investigated the effects of urushiol which was isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), on the proliferation of MCF-7 human breast cancer cells. Forty-eight hour treatment of urushiol inhibited the growth of breast cancer cells and induced cell DNA fragmentation. This urushiol-induced apoptosis in the MCF-7 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly (ADP-ribose) polymerase. Urushiol also caused a marked increase in the level of p21WAF1/CIP1protein in a p53-dependent manner. Based on our data, urushiol can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to confirm this.
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KEYWORD
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Urushiol, Human breast cancer cells, Apoptosis
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